Monday, March 16, 2015
Obscene Science
It is now possible to visualize the inflammation in mouse joints with special dyes that fluoresce in the infrared, outside of the absorbance wavelength of hemoglobin, but how do you give mice arthritis? The answer is obscenely easy -- inject them with collagen. Then you can watch as their joints become inflamed.
I previously performed lots of Google searches on different aspects of collagen metabolism, so I know that the first ten thousand hits on any search with collagen as a search term result in the how-to’s of collagen injections for the high estrogen lip look.
Let’s go one step further. From my work on developing special methods for highly selective antibody production, I know that mice and other animals produce the most heightened, extreme reactions to the smallest amount of antigen when injected in critical areas such as toe pads or .....lips.
Putting this all together, shouldn’t injecting collagen into lips also be a great way for producing arthritis? At one point I put the pieces together for myself and did a search of collagen injection + side effect + arthritis, and guess what? As you might expect, if you inject your lips with collagen, you can produce arthritis. From my work on inflammation, I would suggest that you could use lip injection as a way of measuring the level of chronic inflammation. Inject collagens in the lips and measure the length of time until joint pain starts -- the shorter the time, the higher the level of chronic inflammation.
People ask why I am afraid of high fructose corn syrup. Let’s turn to animal models of disease once again for another example of obscene science. This time we are trying to study type II diabetes. How can I get mice to exhibit diabetes, so that I can study treatments that block the development or reverse diabetes? The answer is just feed them HFCS and they develop diabetes. That doesn’t happen with sucrose. Clearly HFCS is a dangerous sweetener, if you are concerned with diabetes. It is interesting that mice can be protected against HFCS by prior treatment with omega-3 fatty acids. This indicates that type II diabetes development is an inflammatory process.
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